John 'Hombre' Russel is a man raised by the Apaches, in an Indian colony. He lives with them, when he is informed that he has inherited a lodging-house in the city. He goes to the city and decides to trade the place per a herd. He need to move to another city and gets the stagecoach, which is being replaced by the train, in a special trip paid by Faver and his wife Audra. The stagecoach gathers seven very different passengers, and during the journey, they are robbed. With the leadership of John Russel, they escape with little water, the money that the bandits want and having them in their tail. Along their running, most of them reveal their selfish essence, showing the worst of the human race.